Castleman disease is a rare disease of lymph nodes and associated tissues. It is also termed Castleman’s disease, giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH). CD is not cancer but rather called a lymphoproliferative disorder. This implies there is an unusual overgrowth of cells of the lymph system that is akin in many ways to lymphomas (cancers of the lymph nodes). CBD can relieve the symptoms of this condition including unintended weight loss, nausea and inflammation.
What Is Castleman Disease?
Castleman disease is a unique disease of lymph nodes and similar tissues. Sometimes denoted as Castleman’s disease, it is really a group of so-called lymphoproliferative disorders, implying disorders that are marked by abnormal growth (or proliferation) of the lymphatic tissue. The lymphatic (or lymphoid) tissue includes different types of cells that participate in the immune response, mainly white blood cells termed as lymphocytes. Lymphatic tissue is present in lymph nodes, thymus, tonsils, bone marrow, spleen, and gastrointestinal (GI) tract.
Unusual growth of lymphoid tissue too is a feature of lymphoma, a type of cancer, though Castleman disease is not cancer. Different names for Castleman disease are giant lymph node hyperplasia and angiofollicular lymph node hyperplasia (AFH).
Although Castleman disease is not regarded to be cancer, one type of this disease (multicentric Castleman disease) behaves very much as lymph node cancer (lymphoma), and can cause serious health risks.
Causes Of Castleman Disease
Castleman disease happens due to abnormal growth of the type of white blood cells called lymphocytes. However, the precise reasons for this abnormal growth are not completely understood. Elevated levels of a chemical connected with the normal immune response, called interleukin-6 (IL-6), frequently are present in people with multicentric Castleman disease. People having multicentric Castleman disease frequently are discovered to carry a virus called human herpesvirus-8 (HHV-8), also called Kaposi sarcoma herpes virus (KSHV). HHV-8 is frequently found in the lymph node cells in people having multicentric Castleman disease, particularly in those who are HIV positive. This might be responsible for the elevated levels of IL-6.
Symptoms Of Castleman Disease
Many people with unicentric Castleman disease don’t observe any signs or symptoms. The enlarged lymph nodes may be identified during a physical exam or an imaging test for some unrelated problem.
Few people with unicentric Castleman disease might undergo signs and symptoms more common to multicentric Castleman disease, which might include:
- Unintended weight loss
- Night sweats
- Enlarged liver or spleen
The enlarged lymph nodes connected with multicentric Castleman disease are most commonly located in the collarbone, underarms, neck and groin areas.
How CBD Is Effective For Angiofollicular Lymph Node Hyperplasia
CBD has a long history as an effective appetite stimulant and anti-nausea therapy. Besides the anti-inflammatory qualities of CBD makes it an excellent alternative for the treatment of Angiofollicular Lymph Node Hyperplasia.
Useful In Combating Multiple Cancer-Related Symptoms
CBD is effective in combating multiple cancer-related symptoms like anorexia, chemotherapy-induced nausea and vomiting, insomnia, pain, and depression.
Preclinical data indicates that cannabinoids are useful in treating and preventing chemotherapy-induced peripheral neuropathy. Preclinical data suggest cannabinoids may directly impart anti-tumor activity, probably most notably in central nervous system malignancies. Whereas anecdotal evidence is encouraging concerning the curative effects of CBD for breast cancer, large-scale clinical studies are required to test this hypothesis.
Recent studies have documented the potential antitumorigenic properties of CBD in the therapy of different neoplasms, including breast cancer, bladder cancer, lung cancer, glioblastoma, and leukemia. CBD induces these effects through a variety of mechanisms and signaling pathways. For instance, it restricts the growth and metastasis of breast cancer by downregulating the expression of inhibitor of differentiation 1 (ID-1), limits the invasion of lung cancer cells into adjacent tissues by lowering plasminogen activator inhibitor 1 (PAI-1) levels, and induces programmed cell death of bladder cancer cells by affecting a continuous calcium influx.
Aids To Fight Human Herpesvirus
CBD, a phytocannabinoid displays encouraging antitumor effects without causing psychoactive side effects. CBD is emerging as a novel therapeutic for different disorders, including cancer. A study investigated the impact of CBD both on the infection of endothelial cells (ECs) by Kaposi Sarcoma Herpesvirus (KSHV) and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma. While CBD did not affect the efficiency with which KSHV infected ECs, it lessened proliferation and induced apoptosis in those infected by the virus. This indicates a potential mechanism by which CBD casts its effects on KSHV-infected endothelium and upholds the further examination of CBD as a novel targeted agent for the treatment of Kaposi sarcoma.
For Alleviating Pain And Inflammation
The analgesic property of CBD aids to relieve pain emerging from angiofollicular lymph node hyperplasia. CBD also stops the body from absorbing Anandamide, a compound linked with pain regulation. Thereby, CBD can reduce the amount of pain and inflammation. CBD also joins with TRPV1 receptors that operate as ion channels and is known for mediating inflammation, pain sensitivity and body temperature.
CBD may act to fight inflammation and its connected oxidative stress in several ways, like exerting an immunosuppressive effect on macrophages and microglial cells that play a part in inflammation and immunity.
CBD has also been shown to considerably lower chronic inflammatory pain by possibly stimulating glycine receptors. The potent anti-inflammatory effects of CBD are exerted by induction of apoptosis, inhibition of cell multiplication, induction of T-regulatory cells and suppression of cytokine production.
Rapidly absorbed CBD also casts a positive effect on mood. While many pharmaceutical antidepressants may take several weeks to balance out in the body, studies done on rodents indicate a positive effect on mood with just a single dose of CBD. CBD also helps to get a good sleep which is vital to maintain a healthy lymphatic and immune system.